Mast cell activation syndrome (MCAS) is a condition where the allergic system goes haywire. This occurs in many patients with EDS or POTS. Individuals with MCAS are prone to unpredictable rashes, hives or skin sensitivities. They can also experience significant problems from foods, leading to stomach discomfort, diarrhea or constipation.

MCAS can be hard to diagnose. There are blood and urine tests, but these are frequently normal. Through the use of antihistamines, mast cell stabilizers and other medications, the symptoms of MCAS can often be brought under control. Dr. Saperstein and his team are experienced at diagnosing and treating MCAS. When necessary they work with local Allergists specialized in MCAS.